“As a Field Application Scientist, I am often asked some form of the following question: Between NanoSight Pro and Zetasizer Advance Ultra, what is the “better” technology to measure particle concentration? My answer to this question is always the same: It depends.
This is an understandable question, because at first glance, it may not be clear what the differences are between the two instruments. Both Zetasizer and NanoSight instruments use light scattering to measure particles in a liquid and Brownian motion to determine hydrodynamic size. However, the particle concentration measurement principles between the two technologies are fundamentally different. While both instruments measure particle concentration in particles per milliliter (particles/mL), the differences between the two technologies lend themselves to different ideal sample types, mainly relating to size and polydispersity. This blog will explore how these systems compare and contrast to help you make the best choice for your nanoparticle characterization needs. “
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