Field Flow Fractionation is usually abbreviated to the acronym FFF (and sometimes other letters are added).

As a technique it was developed and pioneered by Professor J. Calvin Giddings (1930~1996) of the Chemistry department of the University of Utah and first reported in 1966. It is really a chromatographic principle but it has long been associated with particle sizing technologies. Field Flow Fractionation came to prominence in the mid 1970s and has had analytical success in specific applications. Field Flow Fractionation is coming back into fashion with enviornmental applications, nanoparticle and biotechnology applications, where its unique attributes bring resolution prior to detection.
Professor Giddings founded a company to produce the first generations of FFF instruments called FFFractionation, Inc. in 1986. In 2001 this company joined Postnova analytics to form the market leader, the innovator of the technology. Postnova Analytics GMBh was founded by Dr. Thorsten Klein in 1997. Postnova introduced the world’s first totally integrated automatic and complete Asymmetrical Flow-FFF (AF4) system. Postnova attained its next  milestone 1998 when it presented the first FFF system with on-line coupling to DLS detection for high resolution and fast particle and polymer characterization. These innovations were followed up with static and dynamic laser light scattering, High Temperature Asymmetric Flow FFF for plastic polymers and the first commercial mid Temperature Asymmetric Flow FFF.


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Assyemtric flow FFF