MicroCal ITC

MicroCal ITC isothermal titration calorimeters are used to study a wide range of biomolecular interactions.

The applications range from drug design to fundamental research such as the understanding and regulation of signal transduction pathways.

ITC systems deliver direct, label free and in-solution measurements of binding affinity and thermodynamic parameters in a single experiment.

They all offer  high sensitivity, low sample consumption and options for automation to minimize ‘hands on’ time. A choice of manual and automated  instruments ensures that MicroCal ITC calorimeters meet the varied and demanding requirements of today’s life science laboratories.



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  For MicroCal support contact Malvern HQ in England.


The newest “kid on the block” is MicroCal PEAQ ITC that is designed for ease-of-use and exceptional sensitivity. The system directly measures heat released or absorbed during biochemical binding events, from which it calculates binding affinity (KD), stoichiometry (n), enthalpy (?H), and entropy (?S). With minimal sample preparation and system optimization data is generated quickly and easily. The wide affinity range enables analysis of weak to high affinity binders, with excellent reproducibility. MicroCal ITC is an essential tool for any research laboratory studying biomolecular interactions where high sensitivity and fast results are paramount.