Crystallisation

Investigating your crystallisation process...

See the wide range of products we're offering for this:

Raman Spectroscopy

Kaiser RXN raman system is powerful for the identification, quantitation and characterisation of crystalline forms in your reactor or pilot crystallisation process.

Laser diffraction sizing

Laser diffraction particle sizing instrument for distributions of crystals from sub micron to over 3 millimeters. With the Hydro Sight accessory you can also "see"  crystals forming and growing.

Process sizing

The Insitec process particle size analyser uses laser diffraction technology to measure particles in the size range 0.1 to 2500 µm. It's installed directly into a dry or wet flow of crystalline material

Nano crystals

Zetasizer Nano can be used to detect and size sub-micron crystals as well as molecular clusters in solutions in pilot and model systems.

Granules

For direct, real time data on the performance of a manufacturing process Parsum probe is worth considering (it adds velocity to size measurement and measures 50-6000 µm crystals)

Process imaging

SOPAT probe and imaging technologies for full automation and process control.  SOPAT-probes precisely measure drops, bubbles or solid matters in real-time from within operating processes

Clusters

A research system used to detect, size and monitor submicron crystals and molecular clusters in solutions by using Nanoparticle Tracking Analysis

Crystal shape

Automated imaging microscope providing the ultimate crystal-by-crystal sizing and shaping tool. Morphologi G3-ID adds Raman spectroscopy to identify the chemical species and polymorphic form of individual crystals

Dynamic Imaging

A dynamic image analyser useful for aqueous or solvent reactions and where the shape of crystals and not just the diameter is important.

Powder flow

Freeman FT4 Universal powder tester, ideal for doing comprehensive powder characterisation 

Crystal melting

Rheolaser Crystal enables monitoring the microstructure evolution depending on temperature in heterogeneous products where the crystallisation behaviour including polymorphic transformation of bulk samples is of concern

Crystallisation overview

Crystallisation - the formation of crystals by precipitation from a solution or melt - is considered to be the single most important unit operation in the pharmaceutical industry. Crystallisation and the crystalline state are more suited to purification, reproducibility and stability than other common states (such as amorphous solids and solutions).

Crystals are solids with long-distance repeating order, and are found in almost every industry. Large-scale examples include the production of salt, silicon crystal wafer and sucrose from sugar beet. Over 90% of all pharmaceutical products contain crystalline ingredients.

 

Key characteristics of crystals are their polymorphic form, size, shape and concentration. Particular Sciences has been enabling the Irish industry to measure these for over 25 years, and continues to push the boundaries.